Serum cholinesterase as a new nutritional indicator for predicting weaning failure in patients

Aim The objective of this study is to examine the correlation between patient serum cholinesterase (SCHE) concentration and weaning failure in context invasive mechanical ventilation (IMV), as well identify predictors ventilator failure. Additionally, investigates potential relationship SCHE nutritional risk for developing more effective strategies. Method A retrospective observational was conducted. sample collected from 227 patients with IMV over 48 h who underwent SBT before weaning. Relevant experimental samples data collection were analyzed at time admission initiation SBT. determined by multifactorial logistic regression propensity matching scores. Results Weaning successful 127 failed 100 patients. Depending on difficulty weaning, 55 these had 45 long-term In crude cohort, day showed that concentrations higher than those (4,514 u/l vs. 3,190 p < 0.01). critical value predicting 3,228 ( Ventilator predicted analysis SCHE, heart rate, PaO 2 SBT, (AUC 0.714; 95% CI 0.647–0.782) better rate 0.618; 0.545–0.690), 0.59; 0.515–0.664). After propensity-matched scores, remained an independent predictor = 0.05). And strongly correlated patient’s difficulties Nutrition Risk Critically Ill (NUTRIC) score also significantly according Spearman’s Conclusion Our revealed experienced exhibited lower values compared successfully Before spontaneous breathing trial (SBT), identified Following (PSM), predictors. Patients levels below should undergo careful evaluation findings suggest malnutrition may be a contributing factor